Maternal Serum 25-Hydroxy Vitamin D Concentrations and Calcium Levels in Preeclamptic Women, Sindh, Pakistan

Objectives: To analyse the levels of serum 25-hydroxyvitamin D 25(OH) Dand calcium concentrations in patients with pre-eclampsia, Hyderabad, Sindh, Pakistan.

Methodology: Cross sectional study was conducted at the Gynaecology and Obstetrics Department, LUHS, Hyderabad during the period of January 2020 to June 2020. Total 150 pregnant women were selected according to predesign Proforma and divided into two groups. 50 females were normal normotensive pregnant women as a control group, 100 were pre-eclamptic patients as case group. Obstetric history, clinical data was gathered and then 5ml of blood sample was collected from each patient. The blood samples were taken for the analysis of 25-hydroxyvitamin D or 25(OH)D and calcium levels. 25(OH)D were performed on chemiluminescence, While calcium concentration of Microlab 300. Data was analysed by using SPSS version 23. Student t-test was used for analysed of continuous variables.

Results: The maternal serum vitamin D and calcium levels were significantly decreased as compared to patient with preeclampsia and normotensive healthy pregnant ladies. The blood pressure also declined in case group with P<0.001.Multinomial logistic regression showed significant odd ratio of Vitamin-D and Calcium deficiency in preeclampsia.

Conclusion: The present study reveals that 25-hydroxyvitamin D, and Calcium levels declined significantly in preeclamptic women, and mighty be biomarker of this life threating disease.