SYNTHESIS OF A NEW SERIES OF AMINO ACID DERIVATIVES OF SUBSTITIUTED COUMARIN AND ITS ANTIMICROBIAL ACTIVITY APPLICATIONS

A series of new substituted coumarin amino acid derivatives have been synthesized, characterized and screened for their (In Vitro) antimicrobial activity against Gram-positive and Gram-negative bacteria as well as for their antifungal activity and (In Vivo) application against plant pathogenic fungus, Fusarium oxysporium the causal agent of beans (Phaseolus vulgaris .L.), plant wilt disease Interestingly, our results show available antimicrobial response of the newly substituted coumarins in two main aspects firstly, (in vitro) the inhibition potential and the types of the effective coumarins compounds tested were more upon the filamentous plant pathogenic fungi than on both Gram positive and Gram-negative bacteria tested ,this may give an indication that the mechanism of the inhibition that exerted upon filamentous fungi as Eukaryotic representative class is completely different from that upon bacteria as Prokaryotic representative class .Secondary,.( In Vivo), some of thenewly substituted coumarins can successfully inhibit the growth of plant pathogenic fungus as Fusarium oxysporium in a different degrees.