Gene Expression Endpoints Following Subchronic Thiamethoxam Exposure in Adult Male Rabbits

R. Elsawasany, Ahmed and A. Deltsov, Alexander and S. El Okle, Osama and I. El Euony, Omnia and V. Pozyabin, Sergey and S. Ostrenko, Konstantin (2022) Gene Expression Endpoints Following Subchronic Thiamethoxam Exposure in Adult Male Rabbits. Annual Research & Review in Biology, 37 (3). pp. 1-9. ISSN 2347-565X

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Abstract

Method: sixteen adult male Chinchilla rabbits were divided into two equal groups. Animals in the first group were treated orally with TMX at dose of 250 mg/kg body weight for 90 days. The second group was served as control.

Result: Obtained results showed that TMX increased the relative weight of some reproductive organs including testis and prostate. Hormonal analysis revealed that, TMX induced a significant elevation in the serum testosterone level, while the concentrations of FSH and LH hormones did not exhibit any alterations between treated and control groups. In addition, LDH-C4, FSHβ and LHβ and GnRHR genes were down regulated in TMX treated group.

Conclusion: Administration of thiamethoxam for 90 days in male rabbits induced a noticeable adverse effect on serum testosterone level and down regulated genes related to male rabbit reproductive performance.

Item Type: Article
Subjects: Asian STM > Biological Science
Depositing User: Managing Editor
Date Deposited: 02 Oct 2023 12:36
Last Modified: 02 Oct 2023 12:36
URI: http://journal.send2sub.com/id/eprint/1952

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