Evaluation of Antioxidant Potential and Pro-Inflammatory Enzymes Inhibitory Activity of Fractions and Macerate from Pandiaka angustifolia (vahl) Hepper

In traditional medicines of Burkina Faso, a variety of ailments are treated with Pandiaka angustifolia (Vahl) Hepper, a shrub from the Amaranthaceae family. Amaranthaceae is one of the families of plants that are frequently used to treat disease. This investigation was made to assess the lipoxygenase and xanthine oxidase inhibitory potentials of hydroacetonic macerate and fractions of Pandiaka angustifolia, as well as the amount of phenolics and flavonoids, antioxidant capacity, and other properties. The findings showed the Dichloromethane Fraction (DCMF) possess the best inhibitory activity of lipoxygenase, a key enzyme involved in inflammatory process with 83.84±1.89% of inhibition, as regards Xanthine Oxidase (XO) inhibiting percentage, n-hexane fraction (n-HF) exhibited the highest percentage of inhibition with 76.22 ± 4.78% at a concentration of 100µg/ml. Evaluation of the phenolic and flavonoid content of the fractions and hydroacetonic macerate revealed that the dichloromethane fraction (DCMF) had the highest phenolic and flavonoid content, respectively. This study demonstrated that P. angustifolia's apolar fractions are a viable natural source for the treatment of disorders associated with inflammation and oxidative stress.