Optimization of Stach Phthalate as a Novel Superdisintegrant in the Formulation of Acyclovir Fast Dissolving Tablets

Fast dissolving tablets are alternative to conventional dosage forms for patients like geriatrics, pediatrics, and bedridden patients, who experience difficulty in swallowing of conventional dosage forms. The current studies objective is to develop and improve acyclovir tablets that dissolve quickly using a brand-new superdisintegrant starch phthalate. Antiviral medication acyclovir has a low bioavailability (15–30%) because it dissolves poorly in water. Our present research goal is to make acyclovir fast-dissolving tablets with the novel superdisintegrant starch phthalate and other well-known superdisintegrants like croscarmellose sodium and crospovidone in order to increase the bioavailability of acyclovir. The formulation of tablets followed a 23 factorial design. Esterification has been used to create starch phthalate. There has been physico-chemical characterisation of the starch phthalate. Acyclovir is the chosen medicine, and tests are done using FTIR (Fourier-transform infrared spectroscopy), TLC (Thin layer chromatography), and DSC (Differential scanning studies) to see if there is any interaction. All tablet formulations passed the tests for hardness, friability, drug content, wetting time, and in vitro drug dissolution. It was determined that each formulation's tablet met pharmacopoeial standards and was of high quality. The study came to the conclusion that starch phthalate improved the drug's ability to dissolve when combined with croscarmellose and crospovidone. Thus, a novel superdisintegrant called starch phthalate can be employed to create tablets that dissolve immediately.