Studies on Synthesis of N-1 Fused Heterocyclic Derivatives Using Potassium Carbonate and PEG- 400 as Green Catalyst

Due to their synthetic utility and extensive variety of pharmacological effects, indole and benzimidazole, as well as their substituted derivatives, help to draw interest. The N-substituted fused heterocyclic compounds are usually physiologically active and could be employed as antitumor medicines. The various reactions reported that reactions of K2CO3 showing its essentiality for a particular reaction due to its characteristics like solubility in water, mild base character, easy availability, eco-friendly, and nontoxic in nature. In the presence and absence of phase transfer catalyst such as PEG-400 and TEBAC, the effect of the ratio of catalyst used anhydrous K2CO3 for its N-1 alkylation or arylation of indole-3-carboxaldehyde and 2-acetylbenzimidazole is observed. The ratio 1:4 of anhydrous K2CO3 along with PEG-400 gives, ease of catalyst handling, mild reaction conditions and reactions carried out at 10-15ºC temperature with excellent yields. The simplicity of the approach makes it attractive for the synthesis of N-fused heterocyclic derivatives that could be employed as biological substitutes.