Perspectives of Therapeutic Apheresis in Acute Kidney Injury

Acute kidney injury is a serious complication of various inflammatory diseases of the abdominal and thoracic cavities, severe injuries and burns, eclampsia and sepsis, and a number of infectious diseases. Considering such a variety of etiologies there is a main pathogenesis feature, which is based on endoxemia with accumulation of a number of toxic products that cause disturbances in the vessels endothelium permeability with perivascular edema associated with decrease in the renal blood flow, glomerular filtration, tubular necrosis and oligoanuria. The most common tactics of treatment is to perform kidney replacement therapy, mainly different methods of hemofiltration. However, not all toxic products are removed and the mortality rate remains quite high. The inclusion of hemosorption and plasmapheresis in the complex of therapeutic measures gives more favorable and stable results, showing a significant reduction of the mortality rate.