Discussing Alzheimer's Disease: Parsing the Pathways Leading to the Disease Based on the Spirochete/Biofilm Hypothesis

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made
biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease,
on which this pathway was based, had been specifically confirmed both clinically and pathologically.
This current work will show putative and plausible individual pathways within that overall pathway that
were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta
amyloid; this has been shown in vitro in pure culture and in vivo. The beta amyloid together with tau
protein leads to hyperphosphorylated tau that leads to neurofibrillary tangles and dendrite
disintegration. Many drugs and environmental states interact with that pathway and generally lead to
further disease progression. (These drugs such as haloperidol, and environmental states such as
hyperosmolality have been known to cause worsening of the disease.) Few things lead to reversal of
the pathway, though L-serine stands out among them. All these pathways would not even exist or be
activated were the spirochetes not present. The above hypothesis is based on observed findings from
patients with Alzheimer’s disease and from pathways known to be generated from those findings.