Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid with Regard to Potential Treatment and Prevention of Alzheimer’s Disease

Alzheimer’s disease (AD) is an infectious disease caused by spirochetes, and these spirochetes form
biofilms, which attract the innate immune system. The innate immune system first responder, Toll-like
receptor 2, generates both NFB and TNF which try to kill the spirochetes in the biofilm, but cannot
penetrate the “slime”. NFB is also responsible for the generation of amyloid beta () which itself is
anti-microbial. A cannot penetrate the biofilm either, and its accumulation leads to destruction of the
cerebral neurocircuitry. Treatment with penicillin (as in tertiary syphilis, the comparator to AD) is
outlined; a biofilm dispersing agent may need to be added to the protocol. Treatment with a
bactericidal antibiotic with a concomitant biofilm disperser seems most reasonable; but, as has been
stated previously, any neurologic damage is irreversible. It is therefore of the utmost importance to
treat early in the course of this disease.