It is Time that Health Authorities Promote the Use of the Ozone as a Biological Modulator in the Treatment of the Chronic Oxidative Stress Diseases

Ozone is a very reactive gas and is toxic for the respiratory system but, under precise rules, it can be
therapeutically useful for human disease with a chronic oxidative stress. Ozone is an extremely
versatile drug and the therapeutic range has been precisely defined to exclude acute and chronic
toxicity. It is remarkable that the majority of patients report a feeling of wellness using prolonged
ozone therapy. Particularly in chronic skin infections and ulcers, which affect millions of patients, the
use of parenteral and topical ozone applications is far more effective than conventional medications
for enhancing healing, simply because ozone disinfects, oxygenates and stimulates cell proliferation.
The critical point remains an exhaustive clinical evaluation of ozone therapy in the outlined diseases.
Orthodox medicine remains skeptical because multi-center and extensive clinical trials are not yet
available owing to the lack of sponsors. An unfavorable combination of factors such as a wrong
dogma, the fact that ozone is one of the worst troposphere pollutants and past misuse of ozone have
led to a poor consideration of ozone therapy. However, basic and clinical work, developed during the
last two decades, clarified both the biochemical and molecular mechanisms of action of ozone in
biology and medicine. A judicious dose of ozone dissolved in blood immediately triggers a cascade of
well defined chemical compounds acting on multiple cellular targets according to well-known
biochemical and molecular pathways. Ozone therapy is proving to be very useful in the dry form of
age-related macular degeneration (AMD), cardiovascular diseases, chronic obstructive pulmonary
disease (COPD), cerebral diseases and healing disorders, where conventional medicine appears
insufficient and too expensive. It is time that World Health Authorities abandon prejudice and
skepticism and start to take advantage of an integrative medical application able to help the majority
of world population. Among complementary medical approaches, ozone therapy is known all over the
world but it is not yet practiced correctly everywhere because of the incomplete knowledge by
improvised ozone therapists. However, on the basis of basic and small clinical studies performed in
the last two decades, it has become clear that ozone, in very small dosages, behaves as a real drug
and the biochemical and molecular mechanism of action are well within orthodox medicine. Ethical
Committees are sometimes reluctant to give permission for clinical trials because they prefer
pharmaceuticals able to pay huge sums for insurance and all clinical tests. The few and small
National Associations of ozone therapy, in comparison to the Pharmaceutical Industries, which
register an annual business of many billion dollars, have no financial power and are unable to support
expensive clinical studies.