Study on Antioxidant Activity and Anticarcinogenic Properties of “Rumput mutiara” {Hedyotis corymbosa (L.) Lam.} and “Pohpohan” {Pilea trinervia (Roxb.) Wight}

The research was conducted to determine the anticarcinogenic properties of “rumput mutiara”
(Hedyotis corymbosa (L.) Lam) and “pohpohan” (Pilea trinervia (Roxb.) Wight), by the microculture
tetrazolium salt (MTT) assay on the human breast carcinoma dependent-hormone (MCF-7) cell lines.
The preliminary results showed that the “rumput mutiara” extract displayed the cytotoxic effects
against MCF-7 with IC50-value of 22,67 μg/ml. However, the “pohpohan” extract did not show the IC50-
value against MCF-7 cell lines. The antioxidative activities of the extracts which could contribute to
their cytotoxic properties were also studied. The “rumput mutiara” extract was found to have higher
antioxidant activity compared with “pohpohan” extract. The strong cytotoxic properties of the “rumput
mutiara” extract could be due to its high antioxidant activity. The combination effect of “rumput
mutiara” and soursop were also studied.