DEVELOPMENT AND VALIDATION OF A METHOD FOR THE DETERMINATION OF MOEXIPRIL IN PHARMACEUTICAL PREPARATIONS

A new, simple and sensitive spectrophotometric method has been developed and validated for determination of the antihypertensive drug, moexiprilHCl (MOXL) in tablets. The method is based on complex formation between MOXL and different metal ions such as Cu2+ and Zn2+ in borate buffer of pH 10.3 for Cu2+ (Procedure A) and 10.5 for Zn2+ (Procedure B). The absorbance of the formed complex is measured at 282 nm for both Cu2+ and Zn2+. Beer’s law is obeyed with a good correlation coefficient (0.9999) in the concentration ranges 5-98 and 5-85µg ml-1 for Cu2+ and Zn2+ complexes, respectively. The molar ratios of the metal complexes are calculated and a proposal of the reaction pathway is consequently postulated. The proposed method was validated according to ICH Guidelines and it was successfully applied for determination of MOXL in its tablet dosage forms.