The Profile of Lymphocyte, Monocyte and Lymphocyte-monocyte Ratio in Colorectal Cancer Patients at Moewardi Hospital the Period from March to April 2019 (Retrospective Research)

Background: Based on Globocan data (2012), the incidence of colorectal cancer in Indonesia is 12.8 per 100,000 adult population, with mortality of 9.5% of all cancer case. The ratio of neutrophil to lymphocytes, ratio of platelets to lymphocyte, C-reactive protein, and albumin are predictors in analyzing the changes that occur before and after treatment (chemotherapy and/or surgery) in patients with carcinoma.

Methods: This was a retrospective study, conducted Moewardi Hospital Surakarta during the period of March - April 2019. In that period there were 226 colorectal cancer patients admitted to the inpatient ward of the Moewardi Hospital. With the Slovin formula, we analyzed data from 70 patients as samples. The normal rate of Lymphocyte are 2% -40%, Monocyte are 2%-8%, and the normal rate of Lymphocyte to Monocyte Ratio are 2,1% – 3,8%.

Results: From the 70 patients analyzed, consisting of 40 male patients (57,1%) and 30 women (42,9%). Based on age distribution, 9% were 31-40 years old, 10% were 41-50 years old, 37% were 51-60 years old, 13% were 61-70 years old, and 4% were over 70 years old. 52.8% of patients showed a decrease in monocyte count, while the remaining 47.2% were normal. 21.4% of patiens increased lymphocyte count, 15.7% of patients decreased lymphocyte count, while 48.6% were normal. From the 70 patients analyzed, 37,1% increased rates of Lymphocyte Monocytes Ratio, 44,3% normal and 13,5% showed a decrease in Lymphocyte-Monocyte Ratio.

Conclusion: In a retrospective study of 70 paents of colorectal cancer showed significant results that 44,3% patients have a normal Lymphocyte-Monocyte Ratio (LMR). Based on gender, it is more affected by men than women with a ratio of 4: 3. The most age distribution is at the age of 51-60 years and the rarest at the age above 70 years. Half of the patients studied showed an increase in lymphocyte count, and only a small proportion had a decreased lymphocyte count.